The WANIDA Fellows

WANIDA > Fellows > DOKPOMIWA Houeffa Adeline Tatiana

Program of Study:
M.Sc Molecular Biology and Genetic Engineering

CEA of affiliation:

Title of the thesis:
Molecular immunity of the co-infection of Wolbachia bacteria and the entomopathogenic fungus Metarhizium pingshaense in Aedes aegypti in the context of dengue control.

WANIDA > Fellows > DOKPOMIWA Houeffa Adeline Tatiana

Start of training:
February 2020

Problem Statement:
Vector control remains the main strategy for dengue control. In the face of increasing insecticide resistance, there is an urgent need to develop biological methods of vector control.

One of the most promising of these is the use of Wolbachia bacteria to inhibit pathogen transmission.

The Wolbachia strain wAu, although a better viral inhibitor in Aedes aegypti, requires the combination of wAu-bearing mosquitoes with an entomopathogen in order to suppress the wild mosquito population and promote the settlement of infected transgenic mosquitoes.

Since the efficacy of this control strategy relies on the ability of wAu to protect only infected transgenic mosquitoes from the entomopathogen, it is essential to understand how wAu protects its host from pathogenicity.

Expected outcome:
To elucidate the immune and molecular basis of Wolbachia wAu’s protection against Metarhizium pingshaense infection in Aedes aegypti for an integrated dengue control strategy using these two microorganisms.

This work provides insight into the possibility of combining Wolbachia wAu and Metarhizium in future control programmes against Aedes aegypti.

The entomopathogenic fungi thus contribute to the elimination of wild mosquitoes and the propagation of infected transgenic mosquitoes, the latter strongly blocking the transmission of the dengue virus.

Abdoulaye Diabate, CEA/ITECH-MTV

Etienne Bilgo, IRSS/MURAZ Centre (Bobo-Dioulasso)

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