of the WANIDA network
Doctorate in Biotechnology
ACE affiliate :
African Center of Excellence for Neglected Tropical Diseases and Forensic Biotechnology (ACENTDFB), Ahmadu Bello University, Zaria-Nigeria.
Thesis title :
Detection and molecular characterization of dengue virus in mosquitoes and pyretic patients in selected regional hospitals in Cameroon.
Dengue infection is a major public health problem worldwide. It is the leading cause of morbidity and mortality in all tropical and subtropical regions of the world, with around 3.9 billion people in 128 countries at risk (WHO, 2018). Also, there are few data on the prevalence, surveillance and epidemiology of dengue in the African, South Asian and Western Pacific regions and in Cameroon in particular. Many febrile illnesses due to dengue may be misdiagnosed as malaria or typhoid fever (Tchuandom et al., 2018). Furthermore, circulating serotypes and genotypes are not well established in Cameroon. Therefore, there is a need to determine the occurrence and phylogeny of serotypes and genotypes in pyretic patients, which could help reduce the disease burden.
The aim of this research will be to determine the occurrence and phylogeny of dengue virus serotypes and genotypes in pyretic patients attending certain hospitals in Cameroon.
At the end of this research, it is expected that,
- Dengue virus (DENV) to be detected in mosquitoes Aedes mosquitoes, and seroprevalence in the region established among febrile patients;
- Circulating DENV serotypes/genotypes and the spatial distribution of infection in the area need to be established.
This research will fill important information gaps, including disease outcomes and accurate disease burden statistics, which could better inform future decision-making regarding dengue control and prevention in certain regions of Cameroon. Dengue mapping can be a valuable tool for determining the source of an epidemic.
Prof. Kwaga Jacob Kwada Paghi (ACENTDFB)
Dr. GraceSaboNok Kia (ACENTDFB)
Prof. Mohammed Nasir Shuaibu (ACENTDFB)
Dr. Peter Kojo Quashie (WACCBIP)